A facile and sensitive method of quantifying glutaminase binding to its inhibitor CB-839 in tissues
نویسندگان
چکیده
منابع مشابه
Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.
Glutamine serves as an important source of energy and building blocks for many tumor cells. The first step in glutamine utilization is its conversion to glutamate by the mitochondrial enzyme glutaminase. CB-839 is a potent, selective, and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC). CB-839 had antiproliferative activity in a triple-negative breast cancer (...
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ژورنال
عنوان ژورنال: Journal of Genetics and Genomics
سال: 2020
ISSN: 1673-8527
DOI: 10.1016/j.jgg.2020.06.001